Quality by Design Assisted Revolutionizing Canagliflozine Analysis and Validation with Green Chemistry Innovations

Abstract

Introduction: Green chemistry, typically referred to as ecologically sustainable chemistry, constitutes a field of inquiry situated within the context of chemistry, wherein the primary objective is to mitigate the adverse impacts related to chemical processes and products.

Objectives: The objective is to promote the advancement of sustainable and eco-friendly treatments by decreasing or completely removing the utilisation of toxic chemicals, minimising the production of hazardous materials, and saving energy and resources. This study observed linearity with a range of concentration between 02-12μg/mL for Canagliflozin (CGFZ).

Methods: The method of solving concurrent equations was utilised to ascertain the concentrations of the medication. The recovery percentage from the parenteral dosage form was determined to be 100.4% along with a standard deviation (SD) of ±0.028, with a sample size of 6. The recovery rates observed in the accuracy study ranged from 99.8-101.05% on average. The observed percentage relative standard deviation (%RSD) demonstrated a value that was much below 2% throughout intra-day evaluations, suggesting a noteworthy degree of precision in the proposed methodology.

Results: The findings from statistical analyses of the technique the validation outcomes indicate that the suggested procedures are suitable for implementation inside the facilitated quality control laboratories.  

Conclusions: The present methodology is deemed appropriate for the quantitative analysis of CGFZ in parenteral dosage formulations, since it effectively eliminates any potential interference from frequently used additives. Hence, this approach can be employed for regular analytical objectives.