Efficacy of Siddha Formulation Sathakuppai Choornam Against CYP- 17α-Hydroxylase Using In-Silico Model for Poly Cystic Ovarian Syndrome

Abstract

Introduction: The polycystic ovarian syndrome (Sinaipai neerkatti) is a heterogeneous disorder characterized by hyper androgenism and chronic anovulation. Most women with PCOS have number of small cysts, or fluid-filled sacs, on their ovaries. They also experience menstrual cycle abnormalities, increased androgen (sex hormone) levels, excess hair growth, acne, and obesity. Siddha system plays an important role in treating and managing PCOS and its risks.

Objective: To find the efficacy of the Siddha formulation Sathakuppai choornam against CYP- 17α-hydroxylase using the In-Silico method that may act as a potential therapeutic agent for management of PCOD.

Methods: The molecular docking study was used for docking against CYP- 17α-hydroxylase

Results: The phytochemical such as Oleic acid and Quercetin reveals maximum of 2-3 interactions with the core active amino acid residues present on the target enzyme CYP- 17α-hydroxylase. 

Conclusion: The bio-active compounds like Oleic acid and Quercetin present in the herbal ingredients possess significant binding against the target enzyme CYP-17α-hydroxylase by interacting with active amino acids. Hence these phyto-components which inhibit the target enzyme CYP-17α-hydroxylase may act as a potential therapeutic agent for the management of PCOD.