Formulation Development and Evaluation of Nanoemulsion based Gels for Nicardipine

Abstract

Objective:

The aim of the current research was to investigate the release of Nicardipine, a poorly water-soluble drug from different formulations in vitro.

Method:

A Nano emulsion (NE) was prepared using caprylocaproyl polyoxyl-8 glycerides, diethylene glycol monoethyl ether, and propylene glycol monolaurate. For enhancing the viscosity, carbopol was used to form an NE-based gel (NEBG).

Results:

The prepared formulations were characterized for physical appearance, droplet size, zeta potential, percentage transmittance, heating–cooling cycles, phase separation, viscosity, drug content, and in vitro drug release using Franz diffusion cells. The mean droplets size for ME and ME-based gel-systems were 116.2±0.452, and 185±2.53 nm respectively, whereas the zeta potential values were −32.3±0.53 mV for the former and -34.5±0.26mV for the latter. No significant variations in the pH nor physical appearance alterations were observed while stability tests were performed. The release rate of Nicardipine formulated as NE or as NEBG had the highest release values (85.35±5.34%) and (76.25±5.26%) after 6h respectively.

Conclusion:

This was statistically significant gel had a higher viscosity suitable for topical administration without dripping. The in vitro result suggested that NE systems are powerful topical vehicles for enhanced penetration of Nicardipine.