Ondansetron Hydrochloride Nasal Drop: A Novel Drug Delivery

Abstract

Introduction: The present work was intended to design alternative dosage form to the conventional tablets of the Ondansetron hydrochloride (OND); as its bioavaibility is approximately 56% when administered via oral route.

Objectives: To prepare novel solution of a drug with Polyethylene glycol (PEG-400), Poloxamer (F68) and Benzalkonium Chloride (BC) and evaluate its ex-vivo permeation.

Methods: A solution was prepared and it was evaluated with respect to pH, stability, drug release. Permeation studies were performed using Franz- diffusion cell through dialysis membrane and sheep nasal mucosa in buffer (7.4 pH).

Result: The formulation followed zero order release when a loading dose of 40 mg OND was used, created a flux of 42µg/cm²h^-1 and penetrated about 1mg/cm² of drug in a day.

Conclusion: Hence, the intranasal solution of OND may present a superior option to conventional tablets and may create reasonable change in the drug therapy for prevention of nausea and vomiting associated with initial and repeat courses of emetogenic chemotherapy or in postoperative emesis.