Comparison of Heart Rate Variability and Lipid Profile Between Subclinical Hypothyroidism and Normothyroid in Metabolic Syndrome Cases: our Experience from Government Medical College, Nagpur

Abstract

Introduction: Thyroid hormone affects lipid metabolism, and numerous studies have found that lipid levels increase as TSH levels rise. Serum low-density lipoprotein-C (LDL-C) levels were observed to be higher in SCH patients in several investigations. Changes in blood high-density lipoprotein-C (HDL-C) and triglyceride (TG) levels under SCH have also yielded contradictory results. Objective: To compare lipid profile between subclinical hypothyroidism and normothyroid in metabolic syndrome cases. Methodology: The present cross- sectional study was carried out in total of 103 cases attending the outpatient department and in-patients of Government Medical College, Nagpur from March 2023 to September 2023. Results: Mean age in SCH was 48.16±13.62 years and in normal patients was 46.22±13.13 years. Mean TG in SCH was 181±57.06 and 138.71±41.89 mg/dl in normal patients (p<0.05). Mean TC in SCH was 185.45±37.2 and 174.25±43.52 mg/dl in normal patients(p>0.05). Mean LDL was 119.32±30.31 mg/dl in SCH and 117.06±40.76 mg/dl in normal patients(p>0.05). Mean HDL was 39.77±10.78 mg/dl in SCH and 42.63±10.14 mg/dl in normal patients(p>0.05). Mean LDL/HDL ratio was 3.08±0.82 in SCH and 2.85±1.08 in normal patients(p>0.05). Conclusion: We observed that serum triglycerides were higher in subclinical hypothyroidism patients as compared to normo-thyroidism cases. We also observed no significant difference in other lipid parameters between subclinical hypothyroidism and normo-thyroidism cases. We observed that the mean heart rate in SCH was higher as compared to normothyroid cases where as mean R-R interval in SCH patients was reduced significantly.