Synthesis of N'-Benzylidene-2-((Substituted-Phenyl) (3-(5-(4- Nitrophenyl) Thiophene-2- Yl) Oxiran-2-Yl) Methoxy) Acetohydrazide and Its Pharmacological Activities

Abstract

A series of novel N'-benzylidene-2-((substituted-phenyl)(3-(5-(4- nitrophenyl)thiophen-2-yl)oxiran- 2-yl) methoxy) acetohydrazide   have been prepared through a multistep synthesis . The key features of this reaction are the incorporation of four heterocyclic rings in the structure of target products, using commonly available and inexpensive catalysts, high yields, and simple reaction conditions. Final salt products were obtained by self-capturing of a proton by the nitrogen of the thiophene moiety. The easy work-up and mild reaction conditions are notable features of this protocol. The antibacterial, and ant inflammatory activities of the synthetic products were examined. Most of the compounds showed good activities in comparison to references.