In Vitro Antidiabetic Activity of Aqueous and Ethanolic Leaf Extracts from Various Medicinal Plants
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Abstract
Momordica balsamina, and Salacia reticulata are recognized for their diverse biological properties, including antibacterial, anticancer, antioxidant, and anti-inflammatory activities. This study aimed to assess the in vitro antidiabetic potential of aerial parts of Momordica balsamina extracts and Slacia reticulata extract through digestive enzymes inhibition assay targeting α-amylase and α-glucosidase, crucial enzymes involved in carbohydrate digestion. Acarbose, aqueous, and ethanolic extracts of Momordica balsamina and Salacia reticulata were evaluated at concentrations ranging from 20 to 100 mg/ml.
The absorbance values for α-amylase and α-glucosidase enzymes were measured at 540nm and 400nm, respectively, using a spectrophotometer. Both aqueous and ethanolic extracts exhibited significant inhibition of α-amylase and α-glucosidase enzymes in a concentration-dependent manner. Moreover, the ethanolic extract displayed greater inhibitory activity compared to the aqueous extract