Anti-Diabetic Activity of Artocarpus heterophyllus (jackfruit) Seed Extract: An in-vitro Study.

Abstract

Introduction:  This study was conducted to identify anti-diabetic activity of the jackfruit seed. Many studies have proved that the jackfruit contain anti-diabetic effect towards diabetic patients. So, this study may help many diabetes patients to manage their diabetes through this kind of natural source.

Aim: To determine the anti-diabetic activity of Artocarpus heterophyllus seed extract in treatment of diabetic patients.

 Materials and methods : Study design: In-vitro study, took place in Tamil Nadu, Chennai. This study was conducted in 2022, at the duration of 6 month. Jack fruit seeds are used in this study, has been collected during jack fruit season (March – June) in Tamil Nadu.

The anti-diabetic effect of ethanolic extract and methanolic extract of jackfruit seeds are proved by the method “glucose uptake by yeast cells”. To get ethanolic extract, steam bath method used and to get methanolic extract, rotary evaporator method was used. Here, the metformin drug was used as standard.

Results: the result shows that the glucose concentration has been decreased in yeast cell, as the jackfruit seed extract concentration was increased. Methanolic extract of jackfruit seed shows more effect through this method, ‘glucose uptake by yeast cell’

Conclusion: this study shows that the extract may prevent the absorption of glucose into the cells.)

Keywords: Jackfruit seed, Artocarpus heterophyllus, Diabetes mellitus, anti-diabetic activity, extraction, glucose uptake by yeast cell, nutrition.