Exploring the Interrelationship of Fasting Triglycerides Glucose Index with Vitamin D in type 2 Diabetes Mellitus with Hypothyroidism

Abstract

Introduction: Thyroid dysfunction in Type 2 Diabetes Mellitus is a pervasive health condition found in the adult population at large. Recent studies have highlighted the need for increased attention to the interplay between these two diseases, as they can affect each other. Therefore, this study aimed to investigate the effect of fasting triglycerides glucose index, a marker of insulin resistance with vitamin D in type 2 diabetes mellitus with hypothyroid dysfunction. 

Objectives: Primary objective to determine the fasting triglycerides glucose index in diabetes mellitus with hypothyroidism dysfunction. To find the correlation between fasting triglycerides glucose index with vitamin D in type 2 diabetes mellitus with hypothyroid population.

Methods: A cross-sectional study was done between December 2023 and February 2024 at Chettinad Hospital and Research Institute, located in Kelambakkam, India. A total of 200 subjects between 35 to 70 years belonging to both genders were included in the study. Participants were categorized into two groups: Group 1 includes 100 patients with type 2 diabetes and hypothyroidism, and the other 100 is control group.

Results: The study shows significant negative correlation between fasting triglycerides glucose index and Vitamin D (P value - 0.02) in type 2 diabetes with hypothyroidism.     ROC curve comparing Vitamin D with type 2 diabetes mellitus with hypothyroid shows AUC of 0.873 implying good accuracy.

Conclusions: The present study exhibited strong relationship between insulin resistance and Vitamin D among type 2 diabetes mellitus with hypothyroidism. Prompt therapeutic intervention with Vitamin D supplements in type 2 diabetes mellitus patients will for sure alleviate the complications and thereby considerably bring down the morbidity.