Antifungal Activities Of Novel Series Of Azetidinyl And Thiazolidinone Derivatives Along With There Characterization.

Abstract

(N ’ substituted aryl hydrazine)  indole 3-carbohydrazine- N”- azetidinyl. (6 and its 
derivative) was synthesized through the interaction of (N ’ substituted aryl hydrazine)  
indole 3-carbohydrazine with chloro acetyl chloride and (N ’ substituted aryl hydrazine)  
indole 3-carbohydrazine- N”-thiazolidinone  (5 and its derivative) was synthesized 
through the interaction of (N ’ substituted aryl hydrazine)  indole 3-carbohydrazine with 
the mercapto acetic acid in presence of anhydrous zinc dichloride. Elemental analyses 
and spectrum research were used to establish the compounds' structures. The 
effectiveness of the newly created compounds as antifungal agents against Aspergillus 
flavus, Aspergillus niger, and Aspergillus fumigatus Candida krusei, Candida albicans, 
and Candida parapsilosis C. glabrata HO5 was assessed.