Effect of Sustain Release Property on the Development of Phenytoin Matrix Tablet by Using Different Polymers

Abstract

In this work, the release property of a sparingly water-soluble phenytoin medication was controlled 
by the use of hydroxy propyl methyl cellulose as a hydrophilic, biodegradable, and biocompatible 
matrix polymer. The various parameters influencing drug release were measured from the 
hydrophilic matrix tablets. This formulations were manufactured using the direct compression 
method. The impact of the drug-to-polymer ratio on drug release was investigated, and the 
formulation was further characterized by physical and chemical characteristics. The findings were 
within reasonable bounds. Correlate the pre-formulation and post-formulation characteristics with 
the dissolution profile in the research report. Out of the eight formulations, F8 has the best sustain 
release characteristics.