CAR-T Cell Therapy for Chronic Lymphocytic Leukemia: A Promising Immunotherapy Approach

Main Article Content

Ali Afnan, Khuzin Dinislam, Narinyan Narina, Demidenko Sergey, Tatiana Chehlan, Nersesyan Kristina, Meshcheryakova Emilia, Ismailova Asmar, Ovchinnikova Natalia, Anopkin Artem, Goleva Oksana, Nikita Korelin, Shah Zeb


This study explores the groundbreaking advancements in CAR T cell therapy for treating Chronic Lymphocytic Leukemia (CLL) and highlights its potential to revolutionize CLL treatment. The urgent need for more effective therapies in CLL and introducing CAR T cell therapy as a promising approach. The discussion on CAR T cell clinical manufacturing is important. Detailed insights into the selection of T cell sources, the crucial steps of T cell activation, genetic modification, and subsequent expansion are presented, emphasizing the critical elements necessary for generating potent and efficient CAR T cell products. Moreover, a comprehensive analysis of the structural components of CAR cells, including the ectodomain, transmembrane domain, and endodomain, highlights their pivotal role in the therapy's functionality. Progressing further, the evolutionary journey of CAR cells, spanning four generations, showcases the iterative refinements made to enhance their efficacy and safety profile. The intricate mechanisms by which CAR T cell therapy combats CLL are elucidated, underlining its powerful antitumor activity and targeting specificity for malignant cells. Additionally, the article sheds light on strategies for optimal target antigen selection, aiming to further enhance the therapy's effectiveness in treating CLL. For safety, the discussion on potential toxicities associated with CAR T cell therapy and the outlines of ongoing efforts to manage and mitigate these adverse events are important. Finally, the study concludes by highlighting recent developments in the field, emphasizing the continuous promise and potential of CAR T cell therapy to transform CLL treatment and improve patient outcomes.

Article Details