Chronotherapeutic Drug Delivery: Exploiting Solid Lipid Nanoparticles for Optimized Circadian Rhythm-Based Treatment Strategies

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Sharad S. Kharat, Moreshwar P. Patil


Chronotherapy, the precise timing of drug administration in accordance with the circadian rhythm of the body, has gained popularity for its ability to increase treatment efficacy while decreasing negative effects. Solid lipid nanoparticles (SLNs) have emerged as a promising technique for accomplishing this timing using targeted drug delivery systems. This Study investigates the function of SLNs in optimising circadian rhythm-based therapeutic techniques. It begins by highlighting the impact of circadian rhythms and focused drug administration to therapeutic outcomes. The paper then digs into SLNs, defining them and outlining their properties and benefits, especially in terms of boosting drug stability and bioavailability.

The article then discusses chronotherapeutic drug delivery concepts, with an emphasis on circadian timing and the difficulties of creating effective systems. This article examines the use of SLNs in chronotherapy, including their formulation and engineering in order to release medications in accordance with circadian rhythms. Strategies for enhancing medication targeting and tissue penetration are also explored. The review highlights the improved treatment efficacy and safety of SLN-based chronotherapy. This method guarantees appropriate drug concentrations during peak activity hours, hence reducing adverse effects and toxicity. It emphasises the synergistic effects of SLNs and chronotherapy in cancer treatment. The paper also looks ahead, analysing developing trends, overcoming clinical translation and regulatory approval obstacles, and considering potential applications outside of oncology. This review concludes with an exhaustive examination of the use of solid lipid nanoparticles in circadian rhythm-based medication delivery.

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