A Study of Urinary Inflammatory Makers and Hba1c Levels in Type 2 Diabetic Nephropathy Patients

Abstract

Introduction: Diabetic nephropathy (DN), the largest single cause of end-stage renal disease, and a medical catastrophe of worldwide dimensions. There is growing evidence that activated innate immunity and inflammation are relevant factors in the pathogenesis of diabetes

mellitus, with convincing data that DM2 includes an inflammatory component. Diabetic nephropathy (DN), defined as albuminuria (albumin excretion rate >300mg/24h) and

declining renal function in patient with known diabetes in absence of urinary tract infection, or any other renal disease.

Material and methods: This study was a case control study carried out in department of

Biochemistry, Index Medical College and Hospital in which the patients were selected as per the inclusion and exclusion criteria. 98 patients of Type 2 Diabetic Nephropathy admitted in Department of Medicine, Index medical collage & hospital, Indore and 98 healthy controls were assessed after taking ethical clearance from the college ethical committee. Written and informed consent was also taken.

Results & Conclusion: The mean FBS of the type 2 diabetic nephropathy subjects was higher (187.55±53.20) than for healthy controls (166.74±27.04) and the mean HbA1c of the type 2 diabetic nephropathy subjects was higher (9.27±2.33) than for healthy controls (8.13±1.48) Similarly, the mean PPBS of type 2 diabetic nephropathy subjects was higher 271.81±83.29 as compared 240.21±48.40 healthy controls.and urinary inflammatory marker also higher in case group compare to control. the mean of Microalbumin Creatinine Ratio is insignificantly higher in case 2.78±5.14 compared to control 1.52±4.14 (p>0.05).