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Due to the unpleasant effects and limited effectiveness of antiepileptic medications, epilepsy—one of the most prevalent severe neurological disorders—is a leading cause of morbidity and mortality. People often look to medicinal plants as a possible gold mine for novel chemicals with healing properties. A. Rich's L. inermis Traditional Ethiopian medicine makes use of a herb called vatke to cure epilepsy. Nevertheless, there has been no scientific study conducted on its anticonvulsant properties. Hence, the purpose of this work was to assess the anticonvulsant activity of L.inermis (A. Rich.) Vatke's solvent fractions and 80% methanol root bark extract in mice. Both the pentylenetetrazole and maximal electroshock-induced seizure tests showed a substantial anticonvulsant effect (p < 0.001) when administered at higher doses of ME400 and BF400 compared to the control. Nonetheless, in the PTZ-induced seizure test, the chloroform fraction exhibited a considerable anticonvulsant effect (p < 0.001), whereas the aqueous fraction exhibited the lowest anticonvulsant activity in both seizure-induced tests. Leaf extract from L.inermis (A. Rich.) was found to include tannins, alkaloids, saponins, flavonoids, phenols, steroids, and terpenoids, according to phytochemical screening.