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Adipose-derived stem cells (ADSC) are increasingly popular due to their potential in wound healing and tissue engineering. Stem cell therapy has limited application, due to the need to maintain cell viability and function as well as safety concerns. It has been increasingly reported that the effects of ASC are largely due to the paracrine effects of secreted factors, which can be accumulated in the conditioned medium (CM). Our aim was to conduct a systematic review of the literature to summarize the scientific work that has been done on ADSC to date. Conclusion show that ADSC can encourage the growth of active tumor cells. Therefore its use must be done carefully. It is recommended that further research is needed to identify potential complications and other problems that may arise from the use of ADSC.