Periodontal Disease in Adults and Associated Risks for Alzheimer’s Disease: Population-Oriented Cross-Sectional Study in Uttar Pradesh

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Neelam Das, Pavan Kumar Addanki


The study identifying the relationship between the longitudinal risks of developing periodontal disease within a group of Alzheimer's sufferers of 231,502,578 individuals. The groups' incidence rates of Alzheimer's disease were contrasted. Cox regression was used to examine the relationship between Parkinson's disease (PD) and Alzheimer's disease, taking into account factors such as comorbidities, age, sex, monthly income, and residence urbanicity. When compared to individuals who had dental prophylaxis and rigorous treatment (0.41% year), the incidence rate of Alzheimer's disease was significantly greater among those who did not receive treatment or had teeth pulled (0.63% annually) (P <.001). The group with Parkinson's disease (PD) who did not receive treatment (hazard ratio (HR) = 1.19, 95% confidence interval (CI) = 1.06–1.25) and the group that had teeth extracted (HR = 1.17, 95% CI = 1.05–1.18) had a higher risk of Alzheimer's disease after controlling for confounders, according to the Cox proportional hazards model. The study also found that severe periodontal disease or non-treatment was associated with an advanced threat of developing Alzheimer's disease.

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