The Effects of Intra-Amygdala Injection of Nicotine and Harmaline on Anxiey- Related Behavior in Adult Male Rat

Abstract

B-carboline alkaloids such as harmaline and nicotine are naturally present in the human food chain.
Plants which contain B-caroline have anxiety and hallucinogenic effects. In this study the change in like –
anxiety behaviors was investigated after intra- amygdala injections of nicotine and harmaline and intra action of
them in male rat. Different doses of Harmaline, Nicotine and its compounds were applied for 30 minutes, before
test of anxiety injection to (CeA) amygdale. Then like anxiety behavior include open arm time and Locomotor
activity, spent open arm time, entriar open arm in maze were examined for 5 minute . Bilateral injection of
Harmaline and Nicotine was decreased in to (CeA) amygdale one-by- one open arm times in control group.
Injections of effective does of Nicotine could increase anxiety effects of Harmaline. Furthermore, Injection of
ineffective doses of drugs has increased anxiety. The results show that Harmaline and Nicotine have anxiety
effects. Also muscarinic and Nicotine receptor have important role in Like- anxiety behaviors. Acetylcholine in
CeA amygdale thorough Nicotine receptors caused anxiety behaviors. Joined injection increased them effective.