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We studied the possible association between genetic variants of the enhancer of the FADS1 and FADS2 genes with a predisposition to obesity using a sample of 450 DNA samples from Yakut volunteers without chronic diseases living in Yakutia. Three groups were formed from them: with normal BMI (n=162), with obesity (n=184) and with pre-obesity (n=104). Analysis of the distribution of alleles of the rs174537 polymorphism of the FADS1 and FADS2 gene enhancer showed a higher frequency of the T allele - from 73.1% to 79.1% in all studied groups. As a result of a comparative analysis of the average body mass index depending on the genotype, it is noted that in the group of obese people in carriers of the TT genotype (BMI = 33.6 ± 0.09) it was significantly higher (td = 3.93, p = 0.0001) than in carriers of the TG genotype (BMI=33.1±0.09). We believe that, in combination with high frequencies of unfavorable alleles of the PNPLA3 and FABP2 genes in the Yakut population, there may be a high risk of diseases associated with lipid metabolism in the liver.