Exploring the Impact of Micro RNAs on Cellular Mechanisms in Diabetic Wound Healing

Abstract

Diabetic wounds pose a significant healthcare challenge, often exhibiting impaired healing processes leading to prolonged morbidity and increased healthcare burdens. Understanding the intricate molecular mechanisms underlying impaired healing is crucial for developing targeted therapeutic strategies. This review explores the role of microRNAs (miRNAs) in cellular mechanisms pertinent to diabetic wound healing. miRNAs, small non-coding RNAs, emerge as critical regulators of gene expression, orchestrating various cellular processes. Specific miRNAs have been implicated in modulating inflammation, angiogenesis, and proliferation, among other pathways crucial for wound healing. Clinical studies and experimental models have shed light on the dysregulated expression patterns of miRNAs in diabetic wounds, highlighting their potential as diagnostic markers and therapeutic targets. Challenges in studying miRNAs in this context persist, necessitating innovative approaches and refined methodologies. However, the therapeutic potential of manipulating miRNA expression offers promising avenues for improving healing outcomes in diabetic wounds. This review consolidates current knowledge, underscores challenges, and identifies future directions in harnessing miRNAs for enhanced therapeutic interventions in diabetic wound healing.