Preparation of Efficient Kit for the Semi-Quantitative Determination of Sarcosine as a cancer marker by Grafting Molecularly Imprinted-Stationary on Glass Plate

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Nahid Farhadgholami, Hamid Hashemi-Moghaddam, Masoud Shaabanzadeh, Saeed Zavareh


This paper presents a novel, rapid, and simple method for the determination of sarcosine. The surface of a glass plate was modified with 3-(methacryloxy)propyltrimethoxysilane. Then, a sarcosine-imprinted polymer was grafted on the glass plate by copolymerization of the vinyl end groups with a functional monomer and a cross-linking agent. The synthesized polymers were characterized by Fourier transform infrared spectroscopy and scanning electron microscopy. In the subsequent step, the determination of sarcosine was conducted using the synthesized kit in optimized conditions. The synthesized grafted plate was able to absorb sarcosine selectively in the presence of other amino acids, showing that the proposed method enabled the rapid determination of sarcosine. 

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