Development of Chronotherapeutic Delivery System for the Oral Administration of Aceclofenac for Rheumatoid Arthritis by Using Different Polymers

Abstract

Chronotherapy denotes the medical aid during which the discharge of the drug within the body is allowed to match with the biological time of the disease and the specified desired action of the drug is shown with the minor side effects. The most fascinating truth of chronotherapy is its ability to deliver the drug in desired concentrations throughout the time of its greatest requirement by the body thereby synchronizing the biological time of diseases or symptoms. Aceclofenac has been shown to possess potent analgesic and anti-inflammatory activities, and as a result of cyclooxygenase-2 blockade, it is more safer than typical NSAIDs. Thus, it is used for the treatment of Rheumatoid Arthritis. Different tablet formulations (F1-F15) were prepared by using different excipients and were coated with different polymers Eudragit S100, Eudragit L100, and HPMC K15M. Trail batches of coated tablets (F1-F6) were prepared using different polymers to optimize the concentration of polymers based on %CDR. Final batches F7-F9 using Eudragit S100; F10-F12 using Eudragit L100 and F13-F15 using HPMC K15M were prepared by varying concentrations of polymer. Press-coated tablets were prepared by direct compression and were subjected to physiochemical evaluation and in-vitro dissolution studies. The results indicated that the release of the drug increased with the decrease in the concentration of the coating polymer. From the results of percentage drug content and percentage CDR, F12 was identified as the best formulation. The drug release kinetics for F12 showed that the drug follows zero-order drug release kinetics and followed the Peppas model.