A Review Article on the Therapeutic Potential of Leaves Extract of Adhatoda vasica on Antiparkinsonism Activity

Abstract

Medicinal plants have been used in treatment since ancient times. Medicinal plants play a central role in disease prevention, and their promotion and use are compatible with all existing prevention strategies. The research and use of medicinal substances of plant origin in the treatment of diseases is increasing every day. Natural and unique medicinal plants are used to treat various diseases and earn income. Ayurveda and other Indian literature have mentioned the use of plants in the treatment of various human health ailments. Medicinal plants are an important resource in the fight against serious diseases worldwide. This study focuses on the knowledge and research related to the medicinal use of plants to confirm their medicinal values ​​and the role, contribution and benefit of medicinal plants in neurodegenerative diseases such as Parkinsonism^[1].

Phytochemical analysis of ELEAV revealed the presence of alkaloids, flavonoids, terpenoids, saponins, phenols and steroids. ELEAV also showed antioxidant capacity with 69.23% inhibition of 1,1-diphenyl-2-picrylhydrazil (DPPH) radical. ELEAV had strong inhibitory effects on the scavenging of nitrogen oxide, superoxide, and hydroxyl radicals, 65.24%, 61.54%, and 61.24%, respectively. In addition, ELEAV showed a concentration-dependent reducing power and a strong inhibitory effect on iron-induced lipid peroxidation. 68.26%) in bovine brain extract. These findings confirm the biological effectiveness of A. vasica as a potential source of natural antioxidants^[1].