Formulation and Evaluation of Ciprofloxacin Hydrochloride Loaded Gastro Retentive in Situ Gel for Treating Peptic Ulcer

Abstract

The objective of the present investigation was to design and evaluate ciprofloxacin hydrochloride loaded gastro retentive in situ gel using different polymers and calcium carbonate as cross-linking agents. Ciprofloxacin hydrochloride is an antibiotic belongs to the class of fluroquinolones and is used as a drug of choice for treating the helicobacter pylori. Various polymers like sodium alginate, HPMC K 100, Xanthum gum, sodium carboxy methyl cellulose and Gellan gum were used. F1-F12 formulations were prepared with the concentration difference 0.3% and 0.6%.  The prepared formulations were assessed for various characteristic tests like viscosity, floating behavior, gelling capacity, invitro dissolution test etc. The percentage drug release of all the formulations between 70-80% and the drug content was found to be between 70-90%. Amongst all these formulations the formulations of F3 is selected as optimized one as it has shown the floating lag time 2.6±0.5, Floating time greater than 12 hours, viscosity 358±1.28, drug content 95.2±0.1 and cumulative drug release of 93.1±1.2. So, F3 formulation has been selected as the optimized one.