Needle-Free Injection Technology: Revolutionizing Drug Delivery

Abstract

In recent years, considerable research has been dedicated to revolutionizing drug delivery methods, ensuring safe and effective administration within the human body. The primary aim of innovative needle-free injection technology is to advance transdermal drug delivery by offering a swift, dependable, painless, cost-effective, and efficient therapeutic approach. Transdermal drug delivery stands as one of the most significant and intricate methods following the oral route. Numerous pharmaceutical treatments, including vaccines, macromolecules, medications, and biopharmaceutical products, find their optimal application in transdermal administration. Within this technology, multiple techniques have been developed, with some still in the developmental stage, to enhance the delivery of therapeutic agents via this pathway. These techniques encompass jet injectors, microneedles, electroporation, iontophoresis, sonoporation, microchips, and laser microporation. Leveraging the fundamental principles underlying these techniques and considering the physicochemical properties of the therapeutic agent, they can be effectively employed to administer a diverse range of medicinal substances swiftly and safely, garnering regulatory approval. These technologies represent a substantial improvement in patient compliance compared to conventional injectable therapies. The ultimate objective of transdermal drug delivery using this technology is to mitigate skin resistance, ensuring the timely and precise delivery of therapeutic agents to the appropriate site, thereby achieving the optimal concentration across the skin necessary to elicit the desired therapeutic effect.