Association of the Leu28pro Polymorphic Markers of the Apoe and Pro12ala of the Pparg2 Gene in Diabetic Nephropathy in Type 2 Diabetes Patients

Abstract

This article presents the results of a study of 129 patients with type 2 diabetes and 110 healthy subjects to determine whether the polymorphic markers Leu28Pro of the APOE gene and Pro12Ala of the PPARG2 gene are associated with the development of diabetic nephropathy (DN). Patients in the main group: 65 patients with disease duration up to 10 years, without diabetic nephropathy (33 patients) and with diabetic nephropathy (32 patients), 64 patients with diabetes lasting more than 10-20 years, with no diabetic nephropathy (31 patients) and diabetic nephropathy (33 patients). Genotyping was carried out by polymerase chain reaction. The study showed that association of Pro allele and Leu/Pro genotype of APOE gene and Ala allele and heterozygous Pro/Ala genotype of PPARG2 gene play significant role in the development of diabetic nephropathy in patients with type 2 diabetes in the studied Uzbek nation.