An In-Depth Survey of Analytical Techniques for Quantifying Antihistamines and Antiasthmatics in Diverse Dosage Forms.
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Abstract
This article presents a comprehensive examination of various analytical methodologies employed in the quantification of antihistamines and antiasthmatics, specifically desloratadine, levocetirizine hydrochloride, fexofenadine hydrochloride, and montelukast sodium, in both dosage forms and biological matrices. The analytical techniques encompass electrometric methods, UV spectroscopy, mass spectroscopy, thin-layer chromatography, high-performance liquid chromatography (HPLC), and high-performance thin-layer chromatography (HPTLC). The investigation systematically addresses the essential analytical validation parameters applicable to each methodology. The study reveals that HPLC and UV-Vis spectrophotometry emerged as the predominantly utilized analytical techniques by the researchers.