In vivo Assessment of Acute Toxicity of Schiff Base Cu (II) and Co (II) complexes derived from L-Leucine and o-Vanillin

Abstract

Schiff bases are compounds containing imines (-C=N-) that have advantageous biological properties including anticancer, antibacterial, and antioxidants among others. Such Schiff-based compounds have become more popular, pushing researchers to create more potent and non-toxic molecules. Thus, the present study has aimed to prepare cobalt (II) and copper (II) Schiff bases complexes and evaluate them for in vivo acute toxicity studies. The prepared compounds have been characterized by utilizing UV-vis, and FT-IR techniques. Simultaneously the change in mean body weight, Alkaline Phosphatase (ALP), Creatinine, and total bilirubin levels of 250 mg/kg, 500 mg/kg and 1000 mg/kg body rat weight has been calculated. Histopathological studies have been observed in the liver and kidney of all treated rats. The results of this study imply that these metal complexes may have therapeutic promise although more in vivo studies into the efficacy and safety of these compounds are required.