Gamma Oryzanol: A Natural Compound with Potential for Treating Polycystic Ovary Syndrome

Abstract

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age. Current management strategies only provide symptomatic relief, and there is a need for better treatments. Gamma-oryzanol, a dietary component found in rice bran oil, has been shown to be effective in reducing insulin sensitivity, weight, and oxidative stress.

Objectives: In this study, PCOS was induced in a rat model using estradiol valerate. Gamma-oryzanol was then administered alone and in combination with clomifene citrate.

Methods: The effects of gamma-oryzanol on estrous cyclicity, fertility, histopathological alterations, estradiol and testosterone levels, and oxidative parameters were evaluated. The results showed that gamma-oryzanol alone and in combination with clomifene citrate had protective effects against the estradiol valerate-induced PCOS rat model.

Results: The best effect was observed in the gamma-oryzanol and clomifene citrate combination group, which was significantly better than the standard treatment group (clomifene citrate alone).

Conclusions: These results suggest that gamma-oryzanol could be used in combination with existing standard treatments to improve the management of PCOS. However, further molecular and clinical studies are needed to confirm these findings.