Cytotoxicity Studies on Novel N-Mannich Bases of Isatin Bearing Heterocyclic Scaffolds Clubbed with Primaquine

Abstract

In this study, a series of novel N-Mannich bases isatin bearing heterocyclic scaffolds clubbed with primaquine were tested against HepG2 cancer cell lines. The conventional MTT assay was used to assess the in vitro cytotoxic activities against hepatocellular carcinoma cell lines. Various compounds showed potential cytotoxic effects on HepG2 cell lines in vitro. Additionally, compounds DSR 11 and DSR 40 exhibited the strongest cytotoxic effect on HepG2 cells in comparison to the conventional medication primaquine.