Neutrophil-to-Lymphocyte Ratio as a Marker of Systemic Inflammation in Hypertensive Individuals: A Cross-Sectional Study

Abstract

Background: Hypertension is increasingly recognized as a chronic inflammatory condition. The neutrophil-to-lymphocyte ratio (NLR) has emerged as a simple and cost-effective marker of systemic inflammation.

Aim: To evaluate the association of NLR with blood pressure and its role as a marker of systemic inflammation in hypertensive individuals.

Methods: This cross-sectional study included 80 participants (40 hypertensive and 40 normotensive). Blood pressure and hematological parameters were recorded, and NLR was calculated. Statistical analysis included chi-square test, t-test, correlation, and logistic regression.

Results: Hypertensive individuals showed significantly higher NLR (3.14 ± 1.02 vs. 1.89 ± 0.61, p < 0.0001). Elevated NLR (≥3.0) was observed in 47.5% of hypertensives compared to 7.5% of normotensives. NLR ≥3.0 was strongly associated with hypertension (OR = 25.33, p < 0.0001).

Conclusion: NLR is significantly elevated in hypertension and may serve as a simple, cost-effective marker of systemic inflammation.