Neuroplasticity Modulation through the Synergy of Theta Burst Stimulation and Mirror Therapy: Motor Functional Recovery of Subacute Ischemic Stroke

Abstract

Introduction: Ischemic stroke often causes motor disability. Neurorehabilitation with Theta Burst Stimulation and mirror therapy is promising for motor function recovery. This study aims to evaluate the efficacy of the combination of TBS and mirror therapy on motor function and brain activity (qEEG) in ischemic stroke patients, compared to TBS therapy alone.

Materials and Methods: This research study was an experimental study with a True Experimental design. Thirty-two ischemic stroke patients with motor impairment were divided into a combination group (TBS + mirror therapy) and a single group. FMA-UE, FMA-LE, and qEEG measurements were performed before and after the intervention, then analyzed using the Wilcoxon and Mann Whitney tests.

Results: The combination group showed significant increases in FMA-UE (p=0.001), FMA-LE (p=0.001), and decreases in qEEG DTABR (p=0.002). The single TBS group also showed significant increases in FMA-UE and FMA-LE, decreases in DTABR also. The combination was significantly more effective in improving Δ FMA-UE (p=0.028), Δ FMA-LE (p=0.007), and changes in Δ DTABR (p=0.043) than either therapy alone.

Conclusions: The combination of Theta Burst Stimulation and mirror therapy is more effective in improving motor function and modulating brain activity in ischemic stroke patients than TBS alone, indicating synergistic potential in supporting neuroplasticity.