Efficacy of Placental Extract in the Management of Oral Submucous Fibrosis -A Systematic Review
Main Article Content
Abstract
Introduction: Oral Submucous Fibrosis (OSMF) is a chronic, progressively debilitating disorder with no standardized treatment protocol. Although placental extract is commonly used for its therapeutic benefits in the management of OSMF, it is not included in recent treatment consensus guidelines due to limited supporting evidence. This systematic review aimed to overcome these lacunae by evaluating the clinical effectiveness of placental extract in OSMF management
Objectives: To comprehensively analyse and compare the clinical effectiveness of intralesional placental extract in the management of OSMF
Methods: All the clinical studies that evaluated the effectiveness of placental extract and compared it with intralesional corticosteroids in the treatment of oral submucous fibrosis were included using extensive database searches conducted in PubMed, Cochrane, ProQuest, and Google Scholar published from January 1st 2015, to November 30st 2025.
Results: Eleven clinical trials (two randomized and nine non-randomized trials) comprising 525 patients fulfilled the inclusion criteria. Patients were monitored for three to twelve months. These findings demonstrated a statistically significant reduction of symptoms of OSMF among individuals receiving intralesional placental extract and corticosteroids
Conclusions: Placental extract demonstrated superior symptomatic improvement in OSMF, particularly in reducing burning sensation, and is supported by a strong safety profile with no documented adverse effects.