Correlation between Serum Ntprobnp with Severity of Acute St Elevation Myocardial Infarction in Relation with Coronary Angiography.

Abstract

BACKGROUND: Acute Myocardial ST-Elevation Complete blockage of a coronary artery causes myocardial infarction (STEMI), a severe cardiovascular event that, if left untreated, can cause serious damage to the heart. Choosing treatment plans and forecasting results depend on timely risk categorization. Although the association between NT-proBNP levels and recognized risk scores such as TIMI, Aldrich, and SYNTAX in acute STEMI patients is still unclear, NT-proBNP may provide additional predictive information when paired with these scores. In patients with acute STEMI, the purpose of this study is to examine the association between NT-proBNP levels and the TIMI risk score, Aldrich score, and SYNTAX score.

METHODOLOGY: The purpose of this study is to determine the relationship between NT-proBNP levels at admission and the severity of coronary artery disease in acute STEMI patients as measured by the TIMI, Aldrich, and SYNTAX scores. The study was conducted at Kauvery Hospital in Chennai for 18 months (2023-2024) and comprised 48 patients with no comorbidities who received primary PCI within 48 hours of symptom onset. The association was analyzed using Pearson or Spearman correlation coefficients, depending on the data distribution.

RESULTS: The results show a high positive association between various scores and NT-proBNP levels. TIMI and SYNTAX scores have a substantial connection (ρ=0.832, p<0.001), suggesting that as TIMI values rise, so do SYNTAX ratings. greater TIMI scores correspond with greater NT-proBNP levels (ρ=0.731, p<0.001), as do higher SYNTAX scores (ρ=0.722, p<0.001). The median variations in NT-proBNP levels between Aldrich score groups are statistically significant (p < 0.001).

CONCLUSION: The study concluded that the high associations between NT-proBNP and the TIMI, SYNTAX, and Aldrich scores suggest that NT-proBNP could be beneficial in regular examinations of STEMI patients. This marker may aid in identifying high-risk patients who would benefit from more aggressive treatment techniques such as early revascularization or advanced medical therapy.