A Comparative Study between the Effects of Propofol and Etomidate in Adults Undergoing Surgeries Under General Anaesthesia.

Abstract

BACKGROUND:

The aim of the study is to compare haemodynamic effects of propofol and etomidate in adult’s surgeries under general anesthesia.

METHODS: 60 patients were enrolled in the study who underwent elective surgeries under general anesthesia and has been assessed individually both intraoperatively and post-operatively. Induction with calculated dose of propofol and etomidate. Pain on injection and myoclonic movements at induction, if occurred were recorded. The heart rate and mean arterial pressure is monitored continuously and recorded before induction, at induction and laryngoscopy followed by 1st, 3rd, 5th and 10th minute after intubation. Episodes of apnoea noted. The obtained result is sent for statistical analysis.

RESULTS: It is observed that propofol (group 1) caused significant hypotension and tachycardia induction in comparison to etomidate. In study, etomidate had showed less cardiovascular depression and minimized the uses of vasopressor agents than other induction agents in sepsis and critically ill patients.

CONCLUSION: Etomidate was found ideal for its hemodynamic stability when compared to propofol along with less incidence of pain on injection, the only drawback being high incidence of myoclonus. The study suggest that etomidate is a better option in patients particularly vulnerable to hemodynamic fluctuation during induction like uncontrolled hypertension, sepsis, critically ill and patients with coronary artery disease.