Synthesis, characterization and structure activity relationship of novel biologically active heteroleptic complexes of tin (IV) with N, O and S donor ligands

Abstract

A series of new heteroleptic complexes of Sn (IV) have been prepared by the reaction of SnCl₄ with nitrogen and oxygen donor 3(2’-hydroxyphenyl)5-(4-substitutedphenyl)Pyrazolines and sulfur donor O,O’-Dialkyl and alkylene Dithiophosphate under inert atmosphere. These newly synthesized complexes have been characterized by using elemental analysis, molecular weight measurements, FTIR, ¹HNMR, ¹³CNMR, ¹¹⁹SnNMR and ³¹PNMR. These investigations suggest that, both ligands (pyrazoline and dithiophosphate) show monoanionic bidentate behavior and coordinate through O_phenolic, N_azomethine and S_{dithiphosphoric} donor groups. The bonding mode of Sn(IV) with both ligands in heteroleptic complexes have been discussed and tentative structure have also been proposed. All these complexes have been screened for antibacterial as well as antifungal activity. Structure activity relationship have also been discussed and these heteroleptic complexes were showing promising activity as compared to standards taken.