Formulation and Evaluation of Nanosuspension Containing Poorly Water Soluble Ciclopirox Olamine as topical antifungal agent

Abstract

Nanosuspension is a Novel concept, that administered topically can increases the residence time of drugs in stratum corneum and epidermis, while decreasing the drug's absorption related side effect throughout the body. It can act as a drug reservoir and by altering the vesicular composition or surface characteristics can change the rate of drug release and the affinity for the target site. The Cilopirox Olamine loaded nanosuspension was developed using Hydroxypropyl methyl cellulose and Poly Vinyl Alcohol to enhance its water solubility and improved topical delivery. The ciclopirox olamine loaded nanosuspension were developed by solvent evaporation method using Tween 80 and ethanol in 1:2 molar ratio, the feasibility of nanosuspension successfully demonstrated in the investigation. The prepared nanosuspension were found to be smooth with good drug content as of 85.50%, better entrapment efficiency as of 92±2.15% having optimum drug release of  85.79±0.743 percent. The partical size Malvern Zeta Sizer found out to be 219.1nm and zeta potential as of-31.1mV.The results revealed that Ciclopirox Olamine loaded nanosuspension can be successfully developed as a topical drug delivery system using polymers HPMC and PVA in the ratio of 1:10 enhancing the particular surface area and bioavailability of nanosuspension. The formulation B7 also show better drug release as compared with marketed formulation. From the present study, it was clear that the nanosuspension enhance the particular surface area, solubility, bioavailability, increase drug loading, reduced dose frequency and give fast onset of action.