Seronegative Autoimmune Encephalitis in a 6-Year-Old Child: Expanding the Paradigm of Autoimmune Neurology

Abstract

Autoimmune encephalitis (AIE) refers to a neuroinflammatory condition [1] characterised by formation of autoantibodies against extracellular, intraneural or synaptic antigens. Its manifestation is diverse and variable ranging from behavioral changes to intractable seizures, sometimes proving fatal. First recognised in 2007 with anti NMDA encephalitis[2], the field has since made many strides with the discovery of many more such antibodies like MOG[3], LGI1[4], mGluR5 [5]. However, seronegative autoimmune encephalitis being a diagnosis of exclusion remains to be one of the pitfalls of therapeutic management.

DOI: https://doi.org/10.52783/jchr.v16.i1.11511