Comparative Evaluation of Low-Level Laser Therapy and Systemic Analgesic in the Management of Temporomandibular Disorders: A Randomized Control Study
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Abstract
Background: Temporomandibular disorders (TMDs) are a leading cause of orofacial pain, often linked to parafunctional habits, stress, and muscular overactivity. Although NSAIDs and muscle relaxants are commonly prescribed, their long-term use may lead to systemic adverse effects. Low-level laser therapy (LLLT) has recently gained attention as a non-invasive alternative with anti-inflammatory and analgesic benefits.
Objective: To compare the efficacy of LLLT with a systemic analgesic–muscle relaxant combination in managing chronic TMD-associated pain.
Methods: A randomized controlled study was conducted on 40 TMD patients diagnosed using RDC/TMD criteria. Participants were randomly divided into two groups (n=20 each). Group 1 received oral ZERODOL-MR (Aceclofenac 100 mg + Tizanidine 2 mg) twice daily for six days, while Group 2 underwent LLLT (830 nm, 4 J/cm², six sessions over three weeks). Pain was evaluated using the Visual Analogue Scale (VAS) at baseline, one week, one month, and six months. Statistical analysis used Mann-Whitney and Friedman tests (p ≤ 0.05).
Results: Both groups showed significant pain reduction (p<0.001). At one month, LLLT showed complete pain relief (VAS=0) versus residual pain in Group 1 (VAS=0.65, p=0.019). Relief persisted at six months, with no adverse effects in the LLLT group.
Conclusion: LLLT provides safe, sustained pain relief and is an effective alternative to pharmacotherapy for chronic TMD management.