Wound Healing Potential of Polyherbal Formulation Containing Pereskia Aculeate, Cinnamomum Verum, Sphagneticola Trilobata, Glycyrrhiza Glabra Extract
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Abstract
The use of herbal plant extracts in wound healing is known through decades, but it is necessary to provide scientific data through reverse pharmacology. The selected plants (Pereskia Aculeate, Cinnamomum Verum, Sphagneticola Trilobata, Glycyrrhiza Glabra) were studied individually for many medicinal activities and good results were obtained. This work is carried out in the combinations of extracts in different ratios and then formation of polyherbal ointment using polyherbal extracts and evaluate for wound healing activity. The formulation was found to contain high amounts of flavonoids, tannins and phenols which facilitate wound healing. Polyherbal formulation prepared from the plant extracts accelerates wound healing process by proliferation and mobilization of fibroblast and keratinocytes, and angiogenesis at the site of injury. It also shows fast contraction of wound with its beneficial improvement in tissue biochemical and antioxidant parameters.