Fabrication of Hydrogel Infused with Geranium Oil Loaded Nanosponges: Pharmaceutical and In-Vivo Evaluation

Abstract

Introduction: Geranium oil is a volatile oil that is derived from the leaves of Pelargonium graveolens and has a variety of pharmacologic effects. The main constituents of the essential oil were citronellol (37.5%), geraniol (6.0%), caryophyllene oxide (3.7%), menthone (3.1%), linalool (3.0%), β-bourbonene (2.7%), iso-menthone (2.1%) and geranyl formate (2.0%).
Objectives:
The formulation was developed to improve safety and efficacy of active component. The rate of drug delivery at targeted site can be achieved through this dosage form. Furthermore, the volatile nature of its main active component may cause volatilization and interaction with other formulation elements. To address these issues, our study intends to develop geranium-loaded nanosponges with improved antifungal properties.
Methods: Solvent Evaporation Technique
Results: Particle size, zeta potential, entrapment efficiency, FESEM, and in vitro release were all tested on the formulated formulations. The nanosponge dispersions were all nanosized, and the nanosponges had a spherical uniform shape with a spongy structure, according to FESEM data.
Conclusions:
The nanosponges made using PVA: EC (1:1) were determined to be superior in the in-vitro release testing, as they displayed sustained drug release from nanosponges and were subsequently selected for antifungal potential investigation. It was evaluated for antifungal efficacy against C. albican, with findings confirming the nanosponges' excellent antifungal activity.