Development and Evaluation of Flurbiprofen Nanogel Drug Delivery System

Abstract

Introduction: Inflammation is a defensive mechanism in the body the immune system recognized damaged cells, irritant, and pathogens and protective response involving immune cell, blood vessel that serves as a mechanism initiating the elimination of noxious agent and of damage tissue inflammation is part of body’s immune response.

Objectives: The purpose of this study was to develop and evaluate nanogel for transdermal delivery of Flurbiprofen.

Methods: Nanogel was prepared by chemical cross-linked gel method. Nanogel was prepared by the following steps using chemical crosslinked gel method. First, Hyaluronic Acid (HA) (Different concentration like 1% w/v, 2%w/v, 3%w/v) were dissolved in distilled water at room temperature for 1 hr and Polyvinyl alcohol (PVA) (Different concentration like 2.5% w/v, 5%w/v, 7.5%w/v) were dissolved in distilled water at 50OC on magnetic stirrer for 12 hour (1 hour for dissolution and further 11hr for to achieve homogeneous solution).

Results: The Optimization of formulation has been carried out through 32 factorial designs with Hyaluronic acid and polyvinyl alcohol concentration (in percentage W/V) as an independent variables and particle size and percentage drug entrapment efficiency and gelling time as dependent variables.

Conclusions: Nanogels are a very promising carrier for the topical administration due to the enhanced delivery of drugs.