Liquid Crystal Schiff’s base esters of Isoniazid with 4-n -Alkoxy benzoic acids derivatives: Antituberculosis Drug

Abstract

Isoniazid LC derivative is a synthetic antimicrobial and one of the most important first-line drugs used in the treatment of tuberculosis since 1952. One new mesogenic homologous series of isoniazid with Schiff’s base ester having Alkyl 4-[(E)-{4-[(pyridin-4-ylcarbonyl)hydrazono]methyl}phenoxy]benzoate have been synthesized & molecular structures were characterized by the standard spectroscopic methods and elemental analysis. Isoniazid Schiff’s base ester synthesized by condensing 4-n alkoxy benzoyloxy benzaldehyde [A] with isoniazid [B] by Schiff’s base method [B] synthesized by condensing in the presence of an alcoholic acidic medium. All members in series is exhibiting nematic-mesophase..