Cutting-Edge Developments in Nanoparticle Systems for Managing Respiratory Ailments

Abstract

Recent advancements in nanotechnology have revolutionized respiratory therapeutics by enabling targeted, controlled, and efficient pulmonary drug delivery. Nanoparticle systems such as lipid, polymeric, and solid lipid nanoparticles, dendrimers, and biomimetic carriers enhance solubility, sustain release, and minimize systemic toxicity. Engineered for inhalation routes, these nano systems ensure deep lung deposition and rapid onset. Innovative fabrication methods—like spray drying, microfluidic synthesis, and surface modification—improve aerodynamic performance and drug stability. Emerging inhalable mRNA vaccines, bio-responsive nanoparticles, and smart inhalers highlight the move toward precision respiratory medicine. However, challenges in scalability, long-term safety, and regulation must be overcome to fully realize the potential of inhalable nanomedicine.

DOI: https://doi.org/10.52783/jchr.v15.i6.11031