Characterization, Anti-Bacterial, Anti-Cancer and Anti- Inflamatory Activity of the Green Synthesized Silver Nano Particles from Grewia Oxyphilla Fruit Extract

Abstract

The synthesis of silver nanoparticles and their potential applications play a vital role in several fields in the advanced world. There are many technologies applied for the synthesis of silver nanoparticles. Some of them are electrochemical method, sonochemical method, sol-gel method, thermal decomposition method, mechanical milling method, and laser ablation method. Apart from the above methods, the green synthesis method is trending now because its applications are performing a significant role in this contemporary world. The availability of the key starting material is more and more easy, low-cost, high-importance, and less toxic to the environment. These nanoparticles are further characterized by using the following instruments: UV-visible absorption spectrophotometer, XRD, FT-IR, FESEM, and EDAX. It performed the good result against the antibacterial activity of gram-negative (E. coli) bacteria and gram-positive (S. aureus) bacteria and anti-cancer activity against MCF-7 breast cancer cells. The antioxidant activity is carried out with DPPH as the standard, and the performance of the silver nanoparticles was good in antioxidant activity. The anti-inflammatory activity of the synthesized silver nanoparticles was tested against BSA (bovine serum albumin). In this test, the denaturation of the protein by the effect of the synthesized silver nanoparticle was almost similar to the effect of acetylsalicylic acid. In this test acetylsalicylicacid was used as a standard.