An Open-Label, Single-Arm Clinical Trial to Evaluate the Effectiveness of Vishagna Mahakashaya in Urticaria with Special Reference to Dooshivishajanya Kotha and Its Effect on Serum IGE Level

Abstract

Introduction: Urticaria is a common allergic manifestation that affects around 20% of individuals at least once in their lifetime. The modern era, characterized by altered diet and lifestyle and increased exposure to synthetic chemicals, leads to bioaccumulation of toxins similar to Dooshivisha in Ayurveda. Such toxins provoke hypersensitivity reactions manifested as Kotha (urticaria). Charaka has mentioned Vishagna Mahakashaya as an effective herbal combination for neutralizing and eliminating Visha (toxins).

Objectives: 1.To assess the clinical effectiveness of Charakokta Vishagna Mahakashaya in Dooshivishajanya Kotha (urticaria).2.To evaluate its effect on serum IgE levels

Methods: An open-label, single-arm clinical trial was conducted on 30 patients aged 20–50 years presenting with chronic urticaria (>6 weeks) and serum IgE >100 IU/ml. Vishagna Mahakashaya decoction (98 ml twice daily before food) was administered for 30 days. Assessment was done on days 1, 15, and 30 using subjective parameters (itching, burning, pricking sensation) and objective parameters (number and size of wheals per 24 hours). Serum IgE levels were measured on the 1st and 30th days. Statistical analysis was performed using paired t-test.

Results: The treatment showed statistically significant improvement (p < 0.001) in subjective and objective parameters. Serum IgE levels reduced significantly after 30 days, confirming the antiallergic and detoxifying effect of Vishagna Mahakashaya.

Conclusions Vishagna Mahakashaya effectively reduced urticarial symptoms and serum IgE levels, indicating its efficacy in Dooshivishajanya Kotha. The formulation may serve as a safe and holistic Ayurvedic alternative for allergic disorders linked to cumulative toxic exposure.