Development And Evaluation of Gastroprotective Mucoadhesive Microspheres for Treatment of Epilepsy
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Abstract
Oral drug delivery systems face challenges such as low bioavailability due to the heterogeneity of the gastrointestinal system, pH of the commensally flora, gastric retention time of the dosage form, surface area, and enzymatic activity. Conventional drug delivery systems may not overcome the issues imposed by the gastrointestinal tract (GIT) such as incomplete release of drugs, decrease in dose effectiveness, and frequent dose requirement. Therefore, the failure of conventional drug delivery systems to retain drugs in the stomach may lead to the development of gastro retentive drug delivery systems. The formulation of lamotrigine microsphere, with mucoadhesive properties, was successfully developed by ionic gelation method. Mucoadhesive microspheres were prepared by simple emulsification phase separation technique. Chitosan mucoadhesive microspheres are known to swell in aqueous environments, due to hydration. As a new polymeric structure is formed by introducing bridges between polymeric chains during the cross-linking procedure, Such a structure can be characterized by lower and slower penetration of the solvent through the chain structure of the polymer, suggesting that the swelling ratio and hence the drug release characteristics of the microsphere can be controlled by varying the content of the cross-linking agent used during the manufacturing process.