Role of Neutrophil-To-Lymphocyte Ratio and Platelets-Lymphocyte Ratio in Hypertension

Abstract

Background: Hypertension is a one of the most common chronic diseases and is a risk factor for cardiovascular disease worldwide. Neutrophils and platelets play a crucial role in the progression of inflammation. Studies have reported, that the Neutrophil-to-lymphocyte ratio (NLR) and Platelet-Lymphocyte ratio (PLR) derived from a complete blood count, are elevated in inflammatory condition but the results were debatable.

Objective- Thus, present study was aimed to assess the association between the NLR and PLR with Blood pressure in hypertensive patients.

Methods: Based on specific inclusion and exclusion criteria, 50 diagnosed Hypertensive subjects and 50 healthy controls were enrolled with their written informed consent. Subject’s anthropomorphic data, clinical history were noted down. In aseptic collection blood samples were collected, and Complete Blood Count (CBC) was carried out. The statistical analysis of data was done by using SPSS software.

Results- Statistically significant elevated level of SBP, DBP, Neutrophil, Lymphocyte, Platelet, NLR and PLR (140.0±6.60; 92.1±5.49; 86.3±4.86; 71.4±6.3; 423849.1(7419); 2.48±0.51; 5263.7(720.5)) were observed in Hypertensive Cases as compared to Controls. Serum SBP and DBP showed significant positive correlation with NLR and PLR (r- .665, .595; .538, .403).

Conclusion- In our study blood pressure showed positive significant correlation with NLR and PLR. In Hypertensive subjects with increase in blood pressure it leads to increase in NLR and PLR. Thus overall, the outcome of the study provides clear insight into the role of these ratios in inflammatory condition such as Hypertension which may acts as a novel, easily accessible and cost-effective inflammatory marker specially in elderly population and suggest the use of these markers as prognostic tools to reduce the severity of the disease.