“Comparison of the Efficacy, Safety, And Hemodynamic Effect of Iv Carbetocin Versus Iv Oxytocin for the Prevention of Primary Postpartum Hemorrhage (PPH); A Leading Cause of Maternal Mortality During Cesarean Section”

Abstract

BACKGROUND: - Postpartum hemorrhage is defined as blood loss above 500 mL after a vaginal birth or 1000 mL after a cesarean delivery according to the International Classification of Diseases (ICD-10). Postpartum depression (PPD) is a mood condition that can affect women after giving birth. Although PPH and PPD are separate disorders, there may be a relationship between them. Major depressive symptoms appear after giving birth, which affects many women globally, with prevalence rates of between 10% and 25%.

AIM: The study aims to compare the efficacy, safety, and hemodynamic effects of IV Carbetocin over IV oxytocin to prevent primary postpartum hemorrhage (PPH) during cesarean section.

METHOD: A total of N=126 Patients were divided into two groups. Group 1(n=63) patients were administered Oxytocin 10 IU STAT, and group 2 (n=63) patients were administered Carbetocin 100 mcg. The drugs' safety and efficacy were evaluated, and postpartum depression levels were studied using the EPDS scale.

RESULT:- The study was carried out over 6 months on 126 patients. The patients were evaluated, and a significant difference was seen in terms of (<0.001**), BP (0.014**), and postpartum depressive symptoms.

CONCLUSION: In conclusion, we found that carbetocin is more effective and safer than oxytocin, suggesting that it may be the better choice for avoiding blood loss. Fewer postpartum depressive symptoms were observed in the carbetocin group compared to the oxytocin group.