Effect of Vitamin D3 Supplementation on Serum Interleukin 6 and Hepcidin Levels in Child with Chronic Kidney Disease

Abstract

Introduction: Chronic kidney disease (CKD) is a global health issue, leading to various complications. Chronic inflammation is common in children with CKD shown by increased interleukin 6 and hepcidin level and decreased vitamin D level. Low vitamin D levels also contribute to hepcidin and interleukin 6 homeostasis.

Objective: To know the effect of vitamin D3 supplementation on serum hepcidin and interleukin 6 levels in children with CKD.

Methods: A prospective cohort design was conducted in Wahidin Sudirohusodo Hospital from September to December 2024. Samples were divided into two groups based on GFR. Complete blood count, vitamin D, interleukin 6, and hepsidin level examination were perform before and after supplementation. The data were analyzed with Mann-Whitney Test and Logistic Biner Regression.

Results: Total of 43 children (2 – 18 years old) were included in this study. Characteristics of age, gender, nutritional status, and diagnosis between groups were not significantly different (p > 0.05). After supplementation, vitamin D levels significantly increased in both groups (p = 0.045), while hepcidin levels  and interleukin 6 levels don’t decreased in both group I (p = 0,56 ; p value = 0,082).

Conclusion: Vitamin D 2000 IU supplementation for 6 months increases vitamin D levels in children with CKD but not with hepcidin and interleukin 6 levels.